Sisko could refer to:

People

• Benjamin Sisko, commanding officer of Deep Space 9
• Jake Sisko, Benjamin Sisko's son, and a news reporter
• Jennifer Sisko, Benjamin Sisko's first wife; died at Wolf 359
• Joseph Sisko, Benjamin Sisko's father
• Judith Sisko, daughter of Joseph Sisko, and half-sister to Benjamin
• Kasidy Yates-Sisko, a freighter captain, and Benjamin Sisko's second wife
• Sarah Sisko, Benjamin Sisko's real mother
• Sisko family, an overview of the family tree

People (mirror universe)

• Benjamin Sisko (mirror), the mirror universe counterpart
• Jennifer Sisko (mirror), the mirror universe counterpart

Other

• Chicken ala Sisko, a chicken dish created by Benjamin Sisko
• Personal log, Benjamin Sisko, Benjamin Sisko's personal diary
• Program Sisko 197, a program to sabotage and disable all major computer systems aboard Deep Space 9
• Sisko's attack ship, the Jem'Hadar ship captured in 2373
• Sisko's Creole Kitchen, Joseph Sisko's restaurant on Earth
• Sisko's house, a home Sisko planned to build on Bajor
• Sisko's lightship, a lightship built by Sisko